Strong

Melatonin

N-acetyl-5-methoxytryptamine

Shortens time to fall asleep by roughly seven minutes on average — real, replicated, and much smaller than the packaging implies. It shifts timing rather than sedating.

Studied 0.5–3 mg Timing 1–2 h before bed Sold as up to 10 mg

Shortens time to fall asleep by roughly seven minutes on average — real, replicated, and much smaller than the packaging implies. It shifts timing rather than sedating.

Placeholder body copy for the prototype.

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Grogginess at higher doses; interacts with some blood thinners.

Used for

One email a week. Graded, not hyped.

What changed in the evidence, what got downgraded, and what quietly turned out to be nothing.

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